Assay Detail
Binding
CHEMBL5112289
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Inhibition of human recombinant DPP4 using H-Gly-Pro-AMC as substrate incubated for 30 mins by fluorescence based microplate reader assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.93 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 8.06 |
| CHEMBL5205289 | — | — | 1 | 7.55 |
| CHEMBL5198237 | — | — | 1 | 7.48 |
| CHEMBL5177166 | — | — | 1 | 7.31 |
| CHEMBL5193531 | — | — | 1 | 4.24 |
| CHEMBL5201114 | — | — | 1 | - |
| CHEMBL5191609 | — | — | 1 | - |
| CHEMBL5193118 | — | — | 1 | - |
| CHEMBL5184240 | — | — | 1 | - |
| CHEMBL5194237 | — | — | 1 | - |
| CHEMBL5203377 | — | — | 1 | - |
| CHEMBL5176469 | — | — | 1 | - |
| CHEMBL5171860 | — | — | 1 | - |
| CHEMBL5206696 | — | — | 1 | - |
| CHEMBL25554 | — | — | 1 | - |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL5191973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5205289 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL5198237 | — | IC50 | = | 33.2 | nM | 7.48 |
| CHEMBL5177166 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5193531 | — | IC50 | = | 57440.0 | nM | 4.24 |
| CHEMBL5201114 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL5191609 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL5193118 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL5184240 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL5194237 | — | IC50 | = | 300200.0 | nM | - |
| CHEMBL5203377 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL5176469 | — | IC50 | = | 326600.0 | nM | - |
| CHEMBL5171860 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL5206696 | — | IC50 | = | 326600.0 | nM | - |
| CHEMBL25554 | — | IC50 | > | 700000.0 | nM | - |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | - | — | - | |
| CHEMBL5191973 | — | IC50 | = | 669300.0 | nM | - |