Assay Detail
Functional
CHEMBL5112396
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Antimalarial activity Plasmodium falciparum Dd2-B2 assessed as inhibition of parasite growth using 2 x 10^5 inocula per well
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of <b>UCB7362</b>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.83 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190700 | — | — | 1 | 8.00 |
| CHEMBL5191783 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190700 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL5191783 | — | IC50 | = | 22.5 | nM | 7.65 |