Assay Detail
Functional
CHEMBL5112763
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Antiviral activity against wild type SARS CoV-2 infected in Vero E6 cells transfected with TMPRSS2 assessed as inhibition of virus induced cytopathic effect incubated for 2 to 3 days in presence of P-gp inhibitor CP-100356 by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.81 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.56 |
| CHEMBL5179778 | — | — | 1 | 7.23 |
| CHEMBL5198073 | — | — | 1 | 7.16 |
| CHEMBL2178720 | N-HYDROXYCYTIDINE | -1.0 | 1 | 6.62 |
| CHEMBL5195394 | — | — | 1 | 6.41 |
| CHEMBL5179611 | — | — | 1 | 6.37 |
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 27.3 | nM | 7.56 |
| CHEMBL5179778 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5198073 | — | EC50 | = | 69.7 | nM | 7.16 |
| CHEMBL2178720 | N-HYDROXYCYTIDINE | EC50 | = | 238.0 | nM | 6.62 |
| CHEMBL5195394 | — | EC50 | = | 389.0 | nM | 6.41 |
| CHEMBL5179611 | — | EC50 | = | 423.0 | nM | 6.37 |
| CHEMBL4777223 | PF-00835231 | EC50 | = | 509.0 | nM | 6.29 |