Assay Detail
Binding
CHEMBL5113162
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Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min followed by substrate addition and measured after 60 mins by fluorescence based analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: <i>In Vitro</i> and <i>In Vivo</i> Anti-Inflammatory Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.92 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590950 | — | — | 1 | 7.21 |
| CHEMBL4449485 | — | — | 1 | 7.00 |
| CHEMBL5170803 | — | — | 1 | 6.37 |
| CHEMBL5193145 | — | — | 1 | 6.10 |
| CHEMBL5169630 | — | — | 1 | 6.04 |
| CHEMBL5202375 | — | — | 1 | 5.94 |
| CHEMBL4473010 | — | — | 1 | 5.86 |
| CHEMBL5204046 | — | — | 1 | 5.67 |
| CHEMBL5207672 | — | — | 1 | 5.62 |
| CHEMBL5199450 | — | — | 1 | 5.41 |
| CHEMBL5185907 | — | — | 1 | 4.98 |
| CHEMBL5171972 | — | — | 1 | 4.86 |
| CHEMBL5197863 | — | — | 1 | - |
| CHEMBL5205807 | — | — | 1 | - |
| CHEMBL5197906 | — | — | 1 | - |
| CHEMBL5191521 | — | — | 1 | - |
| CHEMBL5174746 | — | — | 1 | - |
| CHEMBL4458075 | — | — | 1 | - |
| CHEMBL5185080 | — | — | 1 | - |
| CHEMBL5192930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590950 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4449485 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5170803 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5193145 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5169630 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5202375 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4473010 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5204046 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5207672 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5199450 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5185907 | — | IC50 | = | 10390.0 | nM | 4.98 |
| CHEMBL5171972 | — | IC50 | = | 13860.0 | nM | 4.86 |
| CHEMBL5197863 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5205807 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5197906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5191521 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5174746 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4458075 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5185080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5192930 | — | IC50 | > | 10000.0 | nM | - |