Assay Detail
Binding
CHEMBL5113357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at CRBN/H-PGDS in human KU812 cells assessed as reduction in H-PGDS levels incubated for 24 hrs by Western blotting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KU812 cell line |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Hematopoietic prostaglandin D synthase (CHEMBL4680054) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D<sub>2</sub> synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 10.52 | 10.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076100 | — | — | 1 | 10.73 |
| CHEMBL5207946 | — | — | 1 | 10.62 |
| CHEMBL5200341 | — | — | 1 | 10.56 |
| CHEMBL5193611 | — | — | 1 | 10.15 |
| CHEMBL4238186 | — | — | 1 | - |
| CHEMBL3650200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076100 | — | EC50 | = | 0.0187 | nM | 10.73 |
| CHEMBL5207946 | — | EC50 | = | 0.0238 | nM | 10.62 |
| CHEMBL5200341 | — | EC50 | = | 0.0276 | nM | 10.56 |
| CHEMBL5193611 | — | EC50 | = | 0.0714 | nM | 10.15 |
| CHEMBL4238186 | — | EC50 | - | — | - | |
| CHEMBL3650200 | — | EC50 | - | — | - |