Assay Detail
Binding
CHEMBL5113655
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Inhibition of HDAC1 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.07 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178922 | — | — | 1 | 8.96 |
| CHEMBL487253 | BENDAMUSTINE | 4.0 | 1 | 8.00 |
| CHEMBL5190225 | — | — | 1 | 7.58 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.33 |
| CHEMBL5206074 | — | — | 1 | 7.00 |
| CHEMBL5172893 | — | — | 1 | 6.86 |
| CHEMBL5205968 | — | — | 1 | 6.23 |
| CHEMBL5184593 | — | — | 1 | 6.17 |
| CHEMBL5205944 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178922 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL487253 | BENDAMUSTINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5190225 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5206074 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5172893 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL5205968 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL5184593 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL5205944 | — | IC50 | = | 3380.0 | nM | 5.47 |