Assay Detail
Binding
CHEMBL5113656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.40 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487253 | BENDAMUSTINE | 4.0 | 1 | 8.00 |
| CHEMBL5206074 | — | — | 1 | 6.26 |
| CHEMBL5172893 | — | — | 1 | 5.90 |
| CHEMBL5205968 | — | — | 1 | 5.45 |
| CHEMBL5184593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487253 | BENDAMUSTINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5206074 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL5172893 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5205968 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL5184593 | — | IC50 | > | 20000.0 | nM | - |