Assay Detail
Binding
CHEMBL5113657
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Inhibition of HDAC6 (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.26 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178922 | — | — | 1 | 8.37 |
| CHEMBL5190225 | — | — | 1 | 8.23 |
| CHEMBL487253 | BENDAMUSTINE | 4.0 | 1 | 8.00 |
| CHEMBL5192518 | — | — | 1 | 7.82 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL5182686 | — | — | 1 | 7.46 |
| CHEMBL5205968 | — | — | 1 | 7.40 |
| CHEMBL5172893 | — | — | 1 | 6.29 |
| CHEMBL5202439 | — | — | 1 | 5.89 |
| CHEMBL5205944 | — | — | 1 | 5.39 |
| CHEMBL5184593 | — | — | 1 | - |
| CHEMBL5206074 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178922 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5190225 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL487253 | BENDAMUSTINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5192518 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5182686 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL5205968 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5172893 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL5202439 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5205944 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5184593 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5206074 | — | IC50 | > | 10000.0 | nM | - |