Assay Detail
Binding
CHEMBL5113658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE9 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL3535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.44 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172893 | — | — | 1 | 8.10 |
| CHEMBL5206074 | — | — | 1 | 7.24 |
| CHEMBL5205968 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172893 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5206074 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5205968 | — | IC50 | = | 107.0 | nM | 6.97 |