Assay Detail
Binding
CHEMBL5113858
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Inhibition of Bcl-2/Bak (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Apoptosis regulator Bcl-2/Bcl-2 homologous antagonist/killer (CHEMBL3885516) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203189 | — | — | 1 | 6.50 |
| CHEMBL5182721 | — | — | 1 | 6.50 |
| CHEMBL539481 | — | — | 1 | 6.31 |
| CHEMBL1269107 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203189 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5182721 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL539481 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1269107 | — | IC50 | = | 31000.0 | nM | 4.51 |