Assay Detail
Binding
CHEMBL5113876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Bcl-xL/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Bcl-xL/Bcl-2-like protein 11 (CHEMBL3883287) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.31 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183108 | — | — | 1 | 6.55 |
| CHEMBL5204188 | — | — | 1 | 6.54 |
| CHEMBL5199461 | — | — | 1 | 6.47 |
| CHEMBL5206049 | — | — | 1 | 6.26 |
| CHEMBL5181865 | — | — | 1 | 6.08 |
| CHEMBL5203252 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183108 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL5204188 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL5199461 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL5206049 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL5181865 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL5203252 | — | Ki | = | 1100.0 | nM | 5.96 |