Assay Detail
Binding
CHEMBL5113886
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Inhibition of Mcl-1/Bim (unknown origin) by ELISA method
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/Bcl-2-like protein 11 (CHEMBL3430887) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.58 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192932 | — | — | 1 | 6.82 |
| CHEMBL5193943 | — | — | 1 | 6.29 |
| CHEMBL5197332 | — | — | 1 | 6.11 |
| CHEMBL5199709 | — | — | 1 | 5.85 |
| CHEMBL5205868 | — | — | 1 | 5.37 |
| CHEMBL3393621 | — | — | 3 | 5.05 |
| CHEMBL5202297 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192932 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5193943 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5197332 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5199709 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5205868 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3393621 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5202297 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL3393621 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3393621 | — | IC50 | = | 12500.0 | nM | 4.90 |