Assay Detail
Binding
CHEMBL5113889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged Mcl-1/Bim (unknown origin) incubated for 15 mins followed by Bim addition measured after 2 hrs by ELISA method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/Bcl-2-like protein 11 (CHEMBL3430887) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.02 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206371 | — | — | 1 | 6.16 |
| CHEMBL5183172 | — | — | 1 | 6.16 |
| CHEMBL5176347 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206371 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5183172 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5176347 | — | IC50 | = | 1800.0 | nM | 5.75 |