Assay Detail
Binding
CHEMBL5113890
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Inhibition of Bcl-xL/Bim (unknown origin) by ELISA method
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Bcl-xL/Bcl-2-like protein 11 (CHEMBL3883287) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.11 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199709 | — | — | 1 | 5.64 |
| CHEMBL5205868 | — | — | 1 | 5.47 |
| CHEMBL3393621 | — | — | 3 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199709 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5205868 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3393621 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3393621 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL3393621 | — | IC50 | = | 19700.0 | nM | 4.71 |