Assay Detail
Binding
CHEMBL5113892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Bcl-xL/Bid (unknown origin) by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Bcl-xL/BH3-interacting domain death agonist (CHEMBL3883285) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Development of Mcl-1 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.87 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183781 | — | — | 1 | 5.52 |
| CHEMBL5196159 | — | — | 1 | 5.46 |
| CHEMBL3265291 | — | — | 1 | 4.48 |
| CHEMBL2030270 | — | — | 1 | 4.00 |
| CHEMBL5186810 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183781 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL5196159 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL3265291 | — | Ki | = | 32990.0 | nM | 4.48 |
| CHEMBL2030270 | — | Ki | = | 99000.0 | nM | 4.00 |
| CHEMBL5186810 | — | Ki | >= | 50000.0 | nM | - |