Assay Detail
Functional
CHEMBL5114023
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.30 | 6.96 |
| GI50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1197989 | — | — | 1 | 6.96 |
| CHEMBL5194065 | — | — | 1 | 6.33 |
| CHEMBL119096 | CRYPTOLEPINE | — | 1 | 5.98 |
| CHEMBL596333 | ISOCRYPTOLEPINE | — | 1 | 5.92 |
| CHEMBL5177604 | — | — | 1 | - |
| CHEMBL5196301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1197989 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5194065 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL119096 | CRYPTOLEPINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL596333 | ISOCRYPTOLEPINE | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL5177604 | — | GI50 | = | 7200.0 | nM | - |
| CHEMBL5196301 | — | GI50 | = | 7700.0 | nM | - |