Assay Detail
Functional
CHEMBL5114034
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Antimalarial activity against Plasmodium falciparum K1 assessed as parasite growth inhibition
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.35 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180189 | — | — | 1 | 8.62 |
| CHEMBL1312050 | — | — | 1 | 8.05 |
| CHEMBL2322213 | — | — | 1 | 7.68 |
| CHEMBL2391246 | — | — | 1 | 7.66 |
| CHEMBL2391249 | — | — | 1 | 7.52 |
| CHEMBL599054 | — | — | 1 | 7.08 |
| CHEMBL2322216 | — | — | 1 | 6.96 |
| CHEMBL2322509 | — | — | 1 | 6.84 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180189 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1312050 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2322213 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2391246 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2391249 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL599054 | — | IC50 | = | 82.7 | nM | 7.08 |
| CHEMBL2322216 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL2322509 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 1696.0 | nM | 5.77 |