Assay Detail

CHEMBL5114041

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Functional

Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

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Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.

Nuthakki VK, Mudududdla R, Bharate SB.
Eur J Med Chem (2022) 227 : 113938 -113938
PubMed 34710743 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.10	7.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1197989	—	—	1	7.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1197989	—	IC50	=	80.0	nM	7.10