Assay Detail
Functional
CHEMBL5114049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum NF54 assessed as parasite growth inhibition
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.54 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322213 | — | — | 1 | 8.59 |
| CHEMBL2391246 | — | — | 1 | 8.08 |
| CHEMBL2322216 | — | — | 1 | 8.05 |
| CHEMBL599054 | — | — | 1 | 7.86 |
| CHEMBL3585413 | — | — | 1 | 7.76 |
| CHEMBL5175787 | — | — | 1 | 7.72 |
| CHEMBL5180513 | — | — | 1 | 7.72 |
| CHEMBL2391249 | — | — | 1 | 7.61 |
| CHEMBL2322509 | — | — | 1 | 7.26 |
| CHEMBL5208279 | — | — | 1 | 7.24 |
| CHEMBL5181218 | — | — | 1 | 7.17 |
| CHEMBL2058009 | — | — | 1 | 7.11 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322213 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2391246 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2322216 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL599054 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL3585413 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL5175787 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5180513 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2391249 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL2322509 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL5208279 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5181218 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2058009 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 1580.0 | nM | 5.80 |