Assay Detail

CHEMBL5114055

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Toxicity

Cytotoxicity against human MRC5 cells assessed as cell growth inhibition

ChEMBL ↗

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Target

MRC5 (CHEMBL614181) ↗

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MRC5 (CHEMBL614181) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MRC5

CHEMBL614181

Anchored from Assay target.

Protein identity MRC5

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Homo sapiens
Cell Type	MRC5
Confidence	1 — Organism
Curated By	Autocuration

Target

MRC5 (CHEMBL614181) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.

Nuthakki VK, Mudududdla R, Bharate SB.
Eur J Med Chem (2022) 227 : 113938 -113938
PubMed 34710743 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.96	4.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL115585	NEOCRYPTOLEPINE	—	1	4.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL115585	NEOCRYPTOLEPINE	IC50	=	11000.0	nM	4.96