Assay Detail
Binding
CHEMBL5114273
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Inhibition of Escherichia coli topoisomerase 4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355578 | — | — | 1 | 8.70 |
| CHEMBL2165063 | — | — | 1 | 8.66 |
| CHEMBL5203552 | — | — | 1 | 8.52 |
| CHEMBL1824041 | — | — | 1 | 8.49 |
| CHEMBL1916542 | — | — | 1 | 8.30 |
| CHEMBL2165064 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355578 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2165063 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5203552 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1824041 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1916542 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2165064 | — | IC50 | = | 48.0 | nM | 7.32 |