Assay Detail
Binding
CHEMBL5114487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat GAT-2 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | L-M(TK-) |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium- and chloride-dependent GABA transporter 2 (CHEMBL4889) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.68 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432737 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432737 | — | IC50 | = | 21000.0 | nM | 4.68 |