Assay Detail
Binding
CHEMBL5115056
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Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.43 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL5203094 | — | — | 1 | 8.28 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL5203184 | — | — | 1 | 8.12 |
| CHEMBL5195261 | — | — | 1 | 8.04 |
| CHEMBL5204971 | — | — | 1 | 7.75 |
| CHEMBL5183126 | — | — | 1 | 7.63 |
| CHEMBL5201519 | — | — | 1 | 7.55 |
| CHEMBL5179294 | — | — | 1 | 7.28 |
| CHEMBL5190695 | — | — | 1 | 7.21 |
| CHEMBL5192106 | — | — | 1 | 7.14 |
| CHEMBL5188494 | — | — | 1 | 7.05 |
| CHEMBL5194070 | — | — | 1 | 6.80 |
| CHEMBL5170382 | — | — | 1 | 6.00 |
| CHEMBL5193206 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL5203094 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL5203184 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL5195261 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL5204971 | — | Ki | = | 17.8 | nM | 7.75 |
| CHEMBL5183126 | — | Ki | = | 23.2 | nM | 7.63 |
| CHEMBL5201519 | — | Ki | = | 28.2 | nM | 7.55 |
| CHEMBL5179294 | — | Ki | = | 52.4 | nM | 7.28 |
| CHEMBL5190695 | — | Ki | = | 62.1 | nM | 7.21 |
| CHEMBL5192106 | — | Ki | = | 71.9 | nM | 7.14 |
| CHEMBL5188494 | — | Ki | = | 88.6 | nM | 7.05 |
| CHEMBL5194070 | — | Ki | = | 157.8 | nM | 6.80 |
| CHEMBL5170382 | — | Ki | = | 1005.0 | nM | 6.00 |
| CHEMBL5193206 | — | Ki | = | 1159.0 | nM | 5.94 |