Assay Detail
Binding
CHEMBL5115322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 8.02 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208315 | — | — | 1 | 9.31 |
| CHEMBL5206449 | — | — | 1 | 9.22 |
| CHEMBL5182032 | — | — | 1 | 9.19 |
| CHEMBL5200499 | — | — | 1 | 9.08 |
| CHEMBL5179613 | — | — | 1 | 9.03 |
| CHEMBL5187868 | — | — | 1 | 8.82 |
| CHEMBL5193389 | — | — | 1 | 8.71 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 8.55 |
| CHEMBL5203239 | — | — | 1 | 8.51 |
| CHEMBL5207040 | — | — | 1 | 8.50 |
| CHEMBL5193726 | — | — | 1 | 8.46 |
| CHEMBL5187601 | — | — | 1 | 8.32 |
| CHEMBL5187489 | — | — | 1 | 8.26 |
| CHEMBL5197019 | — | — | 1 | 8.23 |
| CHEMBL5196374 | — | — | 1 | 8.16 |
| CHEMBL5183302 | — | — | 1 | 8.16 |
| CHEMBL5191144 | — | — | 1 | 8.07 |
| CHEMBL5187532 | — | — | 1 | 8.06 |
| CHEMBL5207617 | — | — | 1 | 8.03 |
| CHEMBL5172694 | — | — | 1 | 8.03 |
| CHEMBL5207653 | — | — | 1 | 7.98 |
| CHEMBL5170705 | — | — | 1 | 7.98 |
| CHEMBL5208081 | — | — | 1 | 7.84 |
| CHEMBL5181452 | — | — | 1 | 7.83 |
| CHEMBL5185114 | — | — | 1 | 7.82 |
| CHEMBL5183677 | — | — | 1 | 7.81 |
| CHEMBL5207090 | — | — | 1 | 7.76 |
| CHEMBL5177033 | — | — | 1 | 7.66 |
| CHEMBL5206184 | — | — | 1 | 7.63 |
| CHEMBL5172580 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208315 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5206449 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5182032 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL5200499 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL5179613 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL5187868 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5193389 | — | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL941 | IMATINIB | IC50 | = | 2.79 | nM | 8.55 |
| CHEMBL5203239 | — | IC50 | = | 3.11 | nM | 8.51 |
| CHEMBL5207040 | — | IC50 | = | 3.15 | nM | 8.50 |
| CHEMBL5193726 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL5187601 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5187489 | — | IC50 | = | 5.53 | nM | 8.26 |
| CHEMBL5197019 | — | IC50 | = | 5.85 | nM | 8.23 |
| CHEMBL5183302 | — | IC50 | = | 6.99 | nM | 8.16 |
| CHEMBL5196374 | — | IC50 | = | 6.88 | nM | 8.16 |
| CHEMBL5191144 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL5187532 | — | IC50 | = | 8.71 | nM | 8.06 |
| CHEMBL5207617 | — | IC50 | = | 9.45 | nM | 8.03 |
| CHEMBL5172694 | — | IC50 | = | 9.26 | nM | 8.03 |
| CHEMBL5207653 | — | IC50 | = | 10.37 | nM | 7.98 |
| CHEMBL5170705 | — | IC50 | = | 10.57 | nM | 7.98 |
| CHEMBL5208081 | — | IC50 | = | 14.47 | nM | 7.84 |
| CHEMBL5181452 | — | IC50 | = | 14.66 | nM | 7.83 |
| CHEMBL5185114 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5183677 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5207090 | — | IC50 | = | 17.45 | nM | 7.76 |
| CHEMBL5177033 | — | IC50 | = | 21.86 | nM | 7.66 |
| CHEMBL5206184 | — | IC50 | = | 23.45 | nM | 7.63 |
| CHEMBL5172580 | — | IC50 | = | 24.65 | nM | 7.61 |
| CHEMBL5188615 | — | IC50 | = | 27.08 | nM | 7.57 |
| CHEMBL5176514 | — | IC50 | = | 28.21 | nM | 7.55 |
| CHEMBL5177838 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL5194721 | — | IC50 | = | 30.06 | nM | 7.52 |
| CHEMBL5202743 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL5203678 | — | IC50 | = | 43.57 | nM | 7.36 |
| CHEMBL5203127 | — | IC50 | = | 49.99 | nM | 7.30 |
| CHEMBL5189577 | — | IC50 | = | 60.06 | nM | 7.22 |
| CHEMBL5193797 | — | IC50 | = | 60.64 | nM | 7.22 |
| CHEMBL5172285 | — | IC50 | = | 128.5 | nM | 6.89 |
| CHEMBL5196757 | — | IC50 | = | 201.51 | nM | 6.70 |