Assay Detail
Functional
CHEMBL5115325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.05 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187532 | — | — | 1 | 6.75 |
| CHEMBL5206449 | — | — | 1 | 6.13 |
| CHEMBL5193389 | — | — | 1 | 6.09 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.96 |
| CHEMBL5207040 | — | — | 1 | 5.68 |
| CHEMBL5203127 | — | — | 1 | 5.43 |
| CHEMBL5197019 | — | — | 1 | 5.42 |
| CHEMBL5172694 | — | — | 1 | 5.41 |
| CHEMBL5179613 | — | — | 1 | 5.33 |
| CHEMBL5208315 | — | — | 1 | 5.30 |
| CHEMBL5183302 | — | — | 1 | 5.30 |
| CHEMBL5187868 | — | — | 1 | 5.28 |
| CHEMBL5200499 | — | — | 1 | 5.27 |
| CHEMBL5187489 | — | — | 1 | 5.09 |
| CHEMBL5207653 | — | — | 1 | 5.09 |
| CHEMBL5185114 | — | — | 1 | 5.08 |
| CHEMBL5182032 | — | — | 1 | 5.06 |
| CHEMBL5181452 | — | — | 1 | 5.05 |
| CHEMBL5193726 | — | — | 1 | 5.05 |
| CHEMBL5187601 | — | — | 1 | 5.01 |
| CHEMBL5206184 | — | — | 1 | 5.00 |
| CHEMBL5203678 | — | — | 1 | 4.99 |
| CHEMBL5203239 | — | — | 1 | 4.98 |
| CHEMBL5177033 | — | — | 1 | 4.98 |
| CHEMBL5170705 | — | — | 1 | 4.96 |
| CHEMBL5193797 | — | — | 1 | 4.91 |
| CHEMBL5176514 | — | — | 1 | 4.81 |
| CHEMBL5172580 | — | — | 1 | 4.79 |
| CHEMBL5177838 | — | — | 1 | 4.68 |
| CHEMBL5207617 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187532 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5206449 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5193389 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL941 | IMATINIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5207040 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5203127 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL5197019 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL5172694 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5179613 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL5208315 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL5183302 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL5187868 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5200499 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL5187489 | — | IC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL5207653 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL5185114 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL5182032 | — | IC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL5181452 | — | IC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL5193726 | — | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL5187601 | — | IC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL5206184 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL5203678 | — | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL5203239 | — | IC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL5177033 | — | IC50 | = | 10460.0 | nM | 4.98 |
| CHEMBL5170705 | — | IC50 | = | 10850.0 | nM | 4.96 |
| CHEMBL5193797 | — | IC50 | = | 12240.0 | nM | 4.91 |
| CHEMBL5176514 | — | IC50 | = | 15480.0 | nM | 4.81 |
| CHEMBL5172580 | — | IC50 | = | 16190.0 | nM | 4.79 |
| CHEMBL5177838 | — | IC50 | = | 20970.0 | nM | 4.68 |
| CHEMBL5207617 | — | IC50 | = | 24540.0 | nM | 4.61 |
| CHEMBL5188615 | — | IC50 | = | 24440.0 | nM | 4.61 |
| CHEMBL5183677 | — | IC50 | = | 26170.0 | nM | 4.58 |
| CHEMBL5207090 | — | IC50 | = | 26420.0 | nM | 4.58 |
| CHEMBL5208081 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL5191144 | — | IC50 | = | 28360.0 | nM | 4.55 |
| CHEMBL5196374 | — | IC50 | = | 29150.0 | nM | 4.54 |
| CHEMBL5189577 | — | IC50 | = | 28830.0 | nM | 4.54 |
| CHEMBL5172285 | — | IC50 | = | 33180.0 | nM | 4.48 |
| CHEMBL5194721 | — | IC50 | = | 40660.0 | nM | 4.39 |
| CHEMBL5202743 | — | IC50 | = | 43770.0 | nM | 4.36 |
| CHEMBL5196757 | — | IC50 | = | 62960.0 | nM | 4.20 |