Assay Detail
Functional
CHEMBL5115329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K-562R cells expressing Bcr-Abl T315I mutant assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K-562R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.23 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.10 |
| CHEMBL5206449 | — | — | 1 | 5.72 |
| CHEMBL5208315 | — | — | 1 | 4.88 |
| CHEMBL5187868 | — | — | 1 | 4.40 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171837 | PONATINIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5206449 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5208315 | — | IC50 | = | 13350.0 | nM | 4.88 |
| CHEMBL5187868 | — | IC50 | = | 40140.0 | nM | 4.40 |
| CHEMBL941 | IMATINIB | IC50 | = | 93010.0 | nM | 4.03 |