Assay Detail
Functional
CHEMBL5115461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.76 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176789 | — | — | 1 | 6.80 |
| CHEMBL5185001 | — | — | 1 | 6.44 |
| CHEMBL5188129 | — | — | 1 | 6.39 |
| CHEMBL5209160 | — | — | 1 | 6.17 |
| CHEMBL5200125 | — | — | 1 | 6.10 |
| CHEMBL5180759 | — | — | 1 | 6.09 |
| CHEMBL5171469 | — | — | 1 | 6.07 |
| CHEMBL5200865 | — | — | 1 | 6.01 |
| CHEMBL5201909 | — | — | 1 | 5.81 |
| CHEMBL5183346 | — | — | 1 | 5.75 |
| CHEMBL5207473 | — | — | 1 | 5.71 |
| CHEMBL5190548 | — | — | 1 | 5.69 |
| CHEMBL5185324 | — | — | 1 | 5.64 |
| CHEMBL5185225 | — | — | 1 | 5.64 |
| CHEMBL5191641 | — | — | 1 | 5.61 |
| CHEMBL5198607 | — | — | 1 | 5.48 |
| CHEMBL5171233 | — | — | 1 | 5.38 |
| CHEMBL5194020 | — | — | 1 | 5.37 |
| CHEMBL5187941 | — | — | 1 | 5.27 |
| CHEMBL5175294 | — | — | 1 | 5.25 |
| CHEMBL5175172 | — | — | 1 | 5.22 |
| CHEMBL5208535 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176789 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5185001 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5188129 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5209160 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5200125 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5180759 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5171469 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5200865 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5201909 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5183346 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5207473 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL5190548 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5185324 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5185225 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5191641 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL5198607 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL5171233 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL5194020 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL5187941 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL5175294 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL5175172 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL5208535 | — | IC50 | = | 14070.0 | nM | 4.85 |