Assay Detail
Functional
CHEMBL5115463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.43 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188129 | — | — | 1 | 5.97 |
| CHEMBL5198607 | — | — | 1 | 5.88 |
| CHEMBL5175172 | — | — | 1 | 5.87 |
| CHEMBL5187941 | — | — | 1 | 5.73 |
| CHEMBL5176789 | — | — | 1 | 5.60 |
| CHEMBL5191641 | — | — | 1 | 5.59 |
| CHEMBL5209160 | — | — | 1 | 5.57 |
| CHEMBL5183346 | — | — | 1 | 5.55 |
| CHEMBL5185001 | — | — | 1 | 5.54 |
| CHEMBL5180759 | — | — | 1 | 5.53 |
| CHEMBL5200125 | — | — | 1 | 5.49 |
| CHEMBL5207473 | — | — | 1 | 5.40 |
| CHEMBL5208535 | — | — | 1 | 5.40 |
| CHEMBL5171233 | — | — | 1 | 5.38 |
| CHEMBL5190548 | — | — | 1 | 5.31 |
| CHEMBL5194020 | — | — | 1 | 5.27 |
| CHEMBL5175294 | — | — | 1 | 5.16 |
| CHEMBL5171469 | — | — | 1 | 5.12 |
| CHEMBL5200865 | — | — | 1 | 5.08 |
| CHEMBL5185225 | — | — | 1 | 5.06 |
| CHEMBL5201909 | — | — | 1 | 5.03 |
| CHEMBL5185324 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188129 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5198607 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5175172 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL5187941 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5176789 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL5191641 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5209160 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL5183346 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL5185001 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL5180759 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL5200125 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5207473 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL5208535 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5171233 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL5190548 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL5194020 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL5175294 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL5171469 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5200865 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL5185225 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL5201909 | — | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL5185324 | — | IC50 | = | 9850.0 | nM | 5.01 |