Assay Detail
Functional
CHEMBL5115594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HN-6 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HN-6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.60 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.08 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.35 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.71 |
| CHEMBL5189736 | — | — | 1 | 7.46 |
| CHEMBL5178230 | — | — | 1 | 7.33 |
| CHEMBL5170564 | — | — | 1 | 7.13 |
| CHEMBL528271 | PARBENDAZOLE | 2.0 | 1 | 6.99 |
| CHEMBL5197212 | — | — | 1 | 6.87 |
| CHEMBL5171969 | — | — | 1 | 6.77 |
| CHEMBL5193427 | — | — | 1 | 6.73 |
| CHEMBL5171386 | — | — | 1 | 6.59 |
| CHEMBL5188080 | — | — | 1 | 6.59 |
| CHEMBL5190301 | — | — | 1 | 6.46 |
| CHEMBL5191226 | — | — | 1 | 6.41 |
| CHEMBL5179938 | — | — | 1 | 6.38 |
| CHEMBL5205577 | — | — | 1 | 6.37 |
| CHEMBL5199534 | — | — | 1 | 6.34 |
| CHEMBL5177402 | — | — | 1 | 6.26 |
| CHEMBL5191842 | — | — | 1 | 6.22 |
| CHEMBL5206940 | — | — | 1 | 6.13 |
| CHEMBL5188150 | — | — | 1 | 6.07 |
| CHEMBL5195139 | — | — | 1 | 6.01 |
| CHEMBL5181970 | — | — | 1 | 6.00 |
| CHEMBL5184981 | — | — | 1 | 5.93 |
| CHEMBL5189060 | — | — | 1 | 5.86 |
| CHEMBL5191652 | — | — | 1 | 5.85 |
| CHEMBL5197146 | — | — | 1 | 5.83 |
| CHEMBL5175668 | — | — | 1 | 5.80 |
| CHEMBL5197171 | — | — | 1 | 5.77 |
| CHEMBL5202514 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.43 | nM | 8.35 |
| CHEMBL107 | COLCHICINE | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL5189736 | — | IC50 | = | 34.9 | nM | 7.46 |
| CHEMBL5178230 | — | IC50 | = | 46.9 | nM | 7.33 |
| CHEMBL5170564 | — | IC50 | = | 74.6 | nM | 7.13 |
| CHEMBL528271 | PARBENDAZOLE | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5197212 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5171969 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5193427 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL5171386 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5188080 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5190301 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL5191226 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL5179938 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL5205577 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL5199534 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL5177402 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL5191842 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL5206940 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL5188150 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL5195139 | — | IC50 | = | 967.0 | nM | 6.01 |
| CHEMBL5181970 | — | IC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL5184981 | — | IC50 | = | 1179.0 | nM | 5.93 |
| CHEMBL5189060 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5191652 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5197146 | — | IC50 | = | 1467.0 | nM | 5.83 |
| CHEMBL5175668 | — | IC50 | = | 1587.0 | nM | 5.80 |
| CHEMBL5197171 | — | IC50 | = | 1693.0 | nM | 5.77 |
| CHEMBL5202514 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5204207 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5171588 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5194741 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5179297 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5169961 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5203328 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5196617 | — | IC50 | > | 2000.0 | nM | - |