Assay Detail
Functional
CHEMBL5115595
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Antiproliferative activity against human CAL-27 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.14 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.99 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.43 |
| CHEMBL5189736 | — | — | 1 | 7.03 |
| CHEMBL5178230 | — | — | 1 | 6.93 |
| CHEMBL5170564 | — | — | 1 | 6.77 |
| CHEMBL528271 | PARBENDAZOLE | 2.0 | 1 | 6.76 |
| CHEMBL5191226 | — | — | 1 | 6.67 |
| CHEMBL5171386 | — | — | 1 | 6.60 |
| CHEMBL5171969 | — | — | 1 | 6.51 |
| CHEMBL5205577 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.01 | nM | 8.52 |
| CHEMBL107 | COLCHICINE | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL5189736 | — | IC50 | = | 93.1 | nM | 7.03 |
| CHEMBL5178230 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5170564 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL528271 | PARBENDAZOLE | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5191226 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL5171386 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL5171969 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL5205577 | — | IC50 | = | 499.0 | nM | 6.30 |