Assay Detail
Functional
CHEMBL5115596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human FaDu cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | FaDu |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.05 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.35 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.30 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.64 |
| CHEMBL5189736 | — | — | 1 | 6.90 |
| CHEMBL5178230 | — | — | 1 | 6.90 |
| CHEMBL5170564 | — | — | 1 | 6.81 |
| CHEMBL528271 | PARBENDAZOLE | 2.0 | 1 | 6.80 |
| CHEMBL5171969 | — | — | 1 | 6.64 |
| CHEMBL5191226 | — | — | 1 | 6.55 |
| CHEMBL5171386 | — | — | 1 | 6.55 |
| CHEMBL5205577 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.48 | nM | 8.35 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.05 | nM | 8.30 |
| CHEMBL107 | COLCHICINE | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL5189736 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5178230 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5170564 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL528271 | PARBENDAZOLE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5171969 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL5191226 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL5171386 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL5205577 | — | IC50 | = | 775.0 | nM | 6.11 |