Assay Detail
Binding
CHEMBL5115638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged human TDP2 expressed in Escherichia coli BL21 using 4-nitrophenyl phenylphosphonate as substrate incubated for 60 mins by EDTA based chromogenic assay
38
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.58 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2420506 | — | — | 1 | 5.58 |
| CHEMBL5193891 | — | — | 1 | 5.27 |
| CHEMBL5200850 | — | — | 1 | 5.00 |
| CHEMBL5198624 | — | — | 1 | 4.96 |
| CHEMBL5179671 | — | — | 1 | 4.92 |
| CHEMBL5187487 | — | — | 1 | 4.77 |
| CHEMBL5176062 | — | — | 1 | 4.72 |
| CHEMBL5204999 | — | — | 1 | 4.70 |
| CHEMBL5200135 | — | — | 1 | 4.70 |
| CHEMBL5189390 | — | — | 1 | 4.70 |
| CHEMBL5201964 | — | — | 1 | 4.68 |
| CHEMBL5202869 | — | — | 1 | 4.66 |
| CHEMBL5174273 | — | — | 1 | 4.60 |
| CHEMBL5200727 | — | — | 1 | 4.60 |
| CHEMBL5186569 | — | — | 1 | 4.58 |
| CHEMBL5171322 | — | — | 1 | 4.58 |
| CHEMBL5189949 | — | — | 1 | 4.55 |
| CHEMBL5172481 | — | — | 2 | 4.54 |
| CHEMBL5195066 | — | — | 1 | 4.51 |
| CHEMBL5186825 | — | — | 1 | 4.50 |
| CHEMBL5191036 | — | — | 1 | 4.50 |
| CHEMBL5179715 | — | — | 2 | 4.48 |
| CHEMBL5183495 | — | — | 1 | 4.47 |
| CHEMBL5199748 | — | — | 1 | 4.44 |
| CHEMBL5179728 | — | — | 1 | 4.41 |
| CHEMBL5187014 | — | — | 2 | 4.39 |
| CHEMBL5206358 | — | — | 1 | 4.39 |
| CHEMBL5185469 | — | — | 1 | 4.38 |
| CHEMBL5195639 | — | — | 1 | 4.28 |
| CHEMBL5183522 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2420506 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5193891 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5200850 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5198624 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5179671 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5187487 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5176062 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5189390 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5204999 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5200135 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5201964 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5202869 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5174273 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5200727 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5186569 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5171322 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5189949 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL5172481 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5195066 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5191036 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5172481 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5186825 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5179715 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5183495 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL5199748 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5179728 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5187014 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL5206358 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL5185469 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL5179715 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5187014 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5195639 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5183522 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL5193479 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL5197378 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL5191896 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL5194831 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5182411 | — | IC50 | > | 100000.0 | nM | - |