Assay Detail
Binding
CHEMBL5115860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length GST-tagged CDK4/Cyclin D1 expressed in Baculovirus expression system by Adapta assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.01 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1989043 | — | — | 1 | 8.15 |
| CHEMBL5171843 | — | — | 1 | 7.89 |
| CHEMBL5184522 | — | — | 1 | 7.89 |
| CHEMBL5206282 | — | — | 1 | 7.82 |
| CHEMBL5200963 | — | — | 1 | 7.82 |
| CHEMBL5185655 | — | — | 1 | 7.57 |
| CHEMBL5185990 | — | — | 1 | 7.54 |
| CHEMBL5178437 | — | — | 1 | 7.43 |
| CHEMBL5175800 | — | — | 1 | 7.28 |
| CHEMBL5170651 | — | — | 1 | 7.09 |
| CHEMBL5169674 | — | — | 1 | 6.97 |
| CHEMBL5182610 | — | — | 1 | 6.97 |
| CHEMBL5180190 | — | — | 1 | 6.87 |
| CHEMBL5200515 | — | — | 1 | 6.83 |
| CHEMBL5173236 | — | — | 1 | 6.79 |
| CHEMBL5180851 | — | — | 1 | 6.67 |
| CHEMBL5194816 | — | — | 1 | 6.66 |
| CHEMBL5203750 | — | — | 1 | 6.64 |
| CHEMBL5180130 | — | — | 1 | 6.62 |
| CHEMBL5199067 | — | — | 1 | 6.58 |
| CHEMBL5200790 | — | — | 1 | 6.58 |
| CHEMBL5208491 | — | — | 1 | 6.58 |
| CHEMBL5189171 | — | — | 1 | 6.51 |
| CHEMBL5177982 | — | — | 1 | 6.50 |
| CHEMBL5190264 | — | — | 1 | 6.46 |
| CHEMBL5190514 | — | — | 1 | 6.32 |
| CHEMBL5180577 | — | — | 1 | 6.17 |
| CHEMBL5195298 | — | — | 1 | - |
| CHEMBL5173735 | — | — | 1 | - |
| CHEMBL5207135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1989043 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5171843 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5184522 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5206282 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5200963 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5185655 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5185990 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5178437 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5175800 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5170651 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5169674 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5182610 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5180190 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5200515 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5173236 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5180851 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL5194816 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL5203750 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL5180130 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5199067 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL5200790 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL5208491 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL5189171 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL5177982 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL5190264 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL5190514 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL5180577 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL5195298 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5173735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5192162 | — | IC50 | > | 10000.0 | nM | - |