Assay Detail
Binding
CHEMBL5115861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length GST-tagged CDK6/Cyclin D1 expressed in Baculovirus expression system by Adapta assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.71 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1989043 | — | — | 1 | 8.40 |
| CHEMBL5206282 | — | — | 1 | 7.77 |
| CHEMBL5185655 | — | — | 1 | 7.75 |
| CHEMBL5171843 | — | — | 1 | 7.68 |
| CHEMBL5184522 | — | — | 1 | 7.54 |
| CHEMBL5185990 | — | — | 1 | 7.50 |
| CHEMBL5175800 | — | — | 1 | 7.47 |
| CHEMBL5200963 | — | — | 1 | 7.42 |
| CHEMBL5178437 | — | — | 1 | 7.21 |
| CHEMBL5170651 | — | — | 1 | 6.81 |
| CHEMBL5182610 | — | — | 1 | 6.78 |
| CHEMBL5180190 | — | — | 1 | 6.66 |
| CHEMBL5180130 | — | — | 1 | 6.57 |
| CHEMBL5169674 | — | — | 1 | 6.46 |
| CHEMBL5180851 | — | — | 1 | 6.34 |
| CHEMBL5173236 | — | — | 1 | 6.30 |
| CHEMBL5190514 | — | — | 1 | 6.23 |
| CHEMBL5200515 | — | — | 1 | 6.19 |
| CHEMBL5194816 | — | — | 1 | 6.17 |
| CHEMBL5208491 | — | — | 1 | 6.12 |
| CHEMBL5203750 | — | — | 1 | 6.09 |
| CHEMBL5190264 | — | — | 1 | 6.05 |
| CHEMBL5200790 | — | — | 1 | 6.04 |
| CHEMBL5177982 | — | — | 1 | 6.04 |
| CHEMBL5189171 | — | — | 1 | 6.01 |
| CHEMBL5180577 | — | — | 1 | 5.85 |
| CHEMBL5199067 | — | — | 1 | 5.81 |
| CHEMBL5173735 | — | — | 1 | - |
| CHEMBL5195298 | — | — | 1 | - |
| CHEMBL5207135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1989043 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5206282 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5185655 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5171843 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5184522 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5185990 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5175800 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5200963 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5178437 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5170651 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5182610 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5180190 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL5180130 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL5169674 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL5180851 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL5173236 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL5190514 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL5200515 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL5194816 | — | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL5208491 | — | IC50 | = | 758.0 | nM | 6.12 |
| CHEMBL5203750 | — | IC50 | = | 805.0 | nM | 6.09 |
| CHEMBL5190264 | — | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL5200790 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL5177982 | — | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL5189171 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL5180577 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5199067 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5173735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5195298 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5192162 | — | IC50 | > | 10000.0 | nM | - |