Assay Detail
Functional
CHEMBL5116009
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Agonist activity at rat SST5
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.46 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174433 | — | — | 2 | 9.51 |
| CHEMBL5195355 | — | — | 2 | 9.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174433 | — | EC50 | = | 0.31 | nM | 9.51 |
| CHEMBL5174433 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL5195355 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL5195355 | — | EC50 | = | 0.3981 | nM | 9.40 |