Assay Detail
Functional
CHEMBL5116250
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Antiproliferative activity against human MM1.S cells assessed as cell viability measured after 7 days by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.39 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 7.66 |
| CHEMBL5180256 | — | — | 1 | 7.63 |
| CHEMBL5195174 | — | — | 1 | 7.39 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 7.15 |
| CHEMBL5190347 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 21.93 | nM | 7.66 |
| CHEMBL5180256 | — | IC50 | = | 23.45 | nM | 7.63 |
| CHEMBL5195174 | — | IC50 | = | 40.28 | nM | 7.39 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 70.17 | nM | 7.15 |
| CHEMBL5190347 | — | IC50 | = | 72.37 | nM | 7.14 |