Assay Detail
Binding
CHEMBL5116538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING in mouse RAW-Lucia ISG cells assessed as ISG activation incubated for 24 hrs by Quanti-luc reagent based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW-Lucia ISG |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.73 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438309 | — | — | 1 | 5.52 |
| CHEMBL5187622 | — | — | 1 | 4.48 |
| CHEMBL5188508 | — | — | 1 | 4.20 |
| CHEMBL5189647 | — | — | 1 | - |
| CHEMBL5174477 | — | — | 1 | - |
| CHEMBL5195931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438309 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5187622 | — | EC50 | = | 32820.0 | nM | 4.48 |
| CHEMBL5188508 | — | EC50 | = | 63690.0 | nM | 4.20 |
| CHEMBL5189647 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5174477 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5195931 | — | EC50 | > | 100000.0 | nM | - |