Assay Detail
Binding
CHEMBL5116583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Kv7.4 (unknown origin) expressed in CHO cells co-expressing GFP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily KQT member 4 (CHEMBL3576) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.45 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185685 | — | — | 1 | 7.06 |
| CHEMBL5200636 | — | — | 1 | 6.50 |
| CHEMBL4549229 | — | — | 1 | 6.18 |
| CHEMBL4458793 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185685 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5200636 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4549229 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4458793 | — | EC50 | = | 910.0 | nM | 6.04 |