Assay Detail
Binding
CHEMBL5116778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of G9a (unknown origin) assessed as effect on H3K9 methylation by cell based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT2 (CHEMBL6032) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.46 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3109630 | — | — | 1 | 8.24 |
| CHEMBL5172085 | — | — | 1 | 8.24 |
| CHEMBL5187766 | — | — | 1 | 7.61 |
| CHEMBL5195846 | — | — | 1 | 7.59 |
| CHEMBL5183771 | — | — | 1 | 7.26 |
| CHEMBL5193402 | — | — | 1 | 7.20 |
| CHEMBL5199280 | — | — | 1 | 6.96 |
| CHEMBL5189772 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3109630 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5172085 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5187766 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL5195846 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL5183771 | — | IC50 | = | 54.4 | nM | 7.26 |
| CHEMBL5193402 | — | IC50 | = | 63.8 | nM | 7.20 |
| CHEMBL5199280 | — | IC50 | = | 109.8 | nM | 6.96 |
| CHEMBL5189772 | — | IC50 | = | 252.4 | nM | 6.60 |