Assay Detail
Functional
CHEMBL5116799
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Cytotoxicity against ER/PR-negative HER2-positive human SK-BR-3 cells harbouring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.41 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 4.85 |
| CHEMBL5182253 | — | — | 1 | 4.46 |
| CHEMBL5169420 | — | — | 1 | 4.28 |
| CHEMBL5187029 | — | — | 1 | 4.06 |
| CHEMBL5201355 | — | — | 1 | - |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5182253 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5169420 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL5187029 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL5201355 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 131000.0 | nM | - |