Assay Detail
Functional
CHEMBL5117155
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Antitumor activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.92 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189018 | — | — | 1 | 5.31 |
| CHEMBL5171524 | — | — | 1 | 5.30 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.08 |
| CHEMBL5183520 | — | — | 1 | 5.08 |
| CHEMBL5199286 | — | — | 1 | 5.02 |
| CHEMBL5183580 | — | — | 1 | 4.89 |
| CHEMBL5209304 | — | — | 1 | 4.88 |
| CHEMBL5188131 | — | — | 1 | 4.87 |
| CHEMBL5208731 | — | — | 1 | 4.83 |
| CHEMBL5198879 | — | — | 1 | 4.64 |
| CHEMBL5200862 | — | — | 1 | 4.61 |
| CHEMBL5201631 | — | — | 1 | 4.54 |
| CHEMBL5180877 | — | — | 1 | - |
| CHEMBL5171583 | — | — | 1 | - |
| CHEMBL5206236 | — | — | 1 | - |
| CHEMBL5191274 | — | — | 1 | - |
| CHEMBL5206283 | — | — | 1 | - |
| CHEMBL5190248 | — | — | 1 | - |
| CHEMBL5176084 | — | — | 1 | - |
| CHEMBL5199367 | — | — | 1 | - |
| CHEMBL5202793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189018 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL5171524 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL5183520 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL5199286 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL5183580 | — | IC50 | = | 12920.0 | nM | 4.89 |
| CHEMBL5209304 | — | IC50 | = | 13350.0 | nM | 4.88 |
| CHEMBL5188131 | — | IC50 | = | 13450.0 | nM | 4.87 |
| CHEMBL5208731 | — | IC50 | = | 14710.0 | nM | 4.83 |
| CHEMBL5198879 | — | IC50 | = | 22770.0 | nM | 4.64 |
| CHEMBL5200862 | — | IC50 | = | 24680.0 | nM | 4.61 |
| CHEMBL5201631 | — | IC50 | = | 28950.0 | nM | 4.54 |
| CHEMBL5180877 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5171583 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5206236 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5191274 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5206283 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5190248 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5176084 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5199367 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5202793 | — | IC50 | > | 30000.0 | nM | - |