Assay Detail
Binding
CHEMBL5117235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis UGM expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
UDP-galactopyranose mutase (CHEMBL4450) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis and evaluation of inhibitors of Mycobacterium tuberculosis UGM using bioisosteric replacement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 4.33 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 4.46 |
| CHEMBL5205229 | — | — | 1 | 4.20 |
| CHEMBL3276007 | — | — | 1 | - |
| CHEMBL5185885 | — | — | 1 | - |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | - |
| CHEMBL5207362 | — | — | 1 | - |
| CHEMBL5197452 | — | — | 1 | - |
| CHEMBL5179369 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL5205229 | — | Kd | = | 63000.0 | nM | 4.20 |
| CHEMBL3276007 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL5185885 | — | Kd | = | 401000.0 | nM | - |
| CHEMBL324842 | ROSMARINIC ACID | Kd | = | 653000.0 | nM | - |
| CHEMBL5207362 | — | Kd | = | 948000.0 | nM | - |
| CHEMBL5197452 | — | Kd | = | 358000.0 | nM | - |
| CHEMBL5179369 | — | Kd | = | 197000.0 | nM | - |