Assay Detail
Functional
CHEMBL5117301
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Antiviral activity against SARS-Cov2 USA-WA1/2020 infected in African green monkey Vero E6 cells assessed as viral plaque reduction measured after 3 days by plaque reduction neutralization test
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.15 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852855 | — | — | 1 | 7.52 |
| CHEMBL5190267 | — | — | 1 | 5.92 |
| CHEMBL5176166 | — | — | 1 | 5.92 |
| CHEMBL5173899 | — | — | 1 | 5.72 |
| CHEMBL5193629 | — | — | 1 | 5.66 |
| CHEMBL5203715 | — | — | 1 | - |
| CHEMBL5177381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852855 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5190267 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5176166 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5173899 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5193629 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5203715 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5177381 | — | EC50 | > | 5000.0 | nM | - |