Assay Detail
Toxicity
CHEMBL5117664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG potassium channel expressed in CHO cells by automated patch clamp electrophysiological assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.86 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74656 | REL-CISAPRIDE | — | 1 | 7.66 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 4.06 |
| CHEMBL5194948 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74656 | REL-CISAPRIDE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2364608 | DORAVIRINE | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL5194948 | — | IC50 | > | 200000.0 | nM | - |