Assay Detail
Functional
CHEMBL5117679
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Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.07 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183440 | — | — | 1 | 9.46 |
| CHEMBL5199279 | — | — | 1 | 9.42 |
| CHEMBL4542119 | — | — | 1 | 8.80 |
| CHEMBL498271 | — | — | 1 | 8.28 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.26 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.58 |
| CHEMBL2170177 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183440 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5199279 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL4542119 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL498271 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2170177 | — | IC50 | = | 2010.0 | nM | 5.70 |