Assay Detail
Binding
CHEMBL5117692
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Inhibition of HDAC11 (unknown origin) measured by fluorometry assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183440 | — | — | 1 | 5.72 |
| CHEMBL5199279 | — | — | 1 | 5.50 |
| CHEMBL96051 | SCRIPTAID | — | 1 | 5.28 |
| CHEMBL4542119 | — | — | 1 | 5.00 |
| CHEMBL5202154 | — | — | 1 | - |
| CHEMBL498271 | — | — | 1 | - |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | - |
| CHEMBL2170177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183440 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5199279 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL96051 | SCRIPTAID | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4542119 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5202154 | — | IC50 | - | — | - | |
| CHEMBL498271 | — | IC50 | - | — | - | |
| CHEMBL99 | TRICHOSTATIN | IC50 | - | — | - | |
| CHEMBL2170177 | — | IC50 | - | — | - |