Assay Detail
Functional
CHEMBL5117861
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel pentanediamide derivatives as S-adenosyl-l-homocysteine hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.49 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182992 | — | — | 1 | 4.84 |
| CHEMBL5202341 | — | — | 1 | 4.78 |
| CHEMBL5191946 | — | — | 1 | 4.69 |
| CHEMBL5200876 | — | — | 1 | 4.64 |
| CHEMBL5199394 | — | — | 1 | 4.54 |
| CHEMBL5180206 | — | — | 1 | 4.45 |
| CHEMBL202701 | — | — | 1 | 4.39 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.32 |
| CHEMBL5177844 | — | — | 1 | 4.12 |
| CHEMBL5194479 | — | — | 1 | 4.12 |
| CHEMBL5199999 | — | — | 1 | - |
| CHEMBL5208972 | — | — | 1 | - |
| CHEMBL5192649 | — | — | 1 | - |
| CHEMBL5188191 | — | — | 1 | - |
| CHEMBL5176164 | — | — | 1 | - |
| CHEMBL5193777 | — | — | 1 | - |
| CHEMBL5199897 | — | — | 1 | - |
| CHEMBL5172872 | — | — | 1 | - |
| CHEMBL5201769 | — | — | 1 | - |
| CHEMBL5203491 | — | — | 1 | - |
| CHEMBL5185075 | — | — | 1 | - |
| CHEMBL5181989 | — | — | 1 | - |
| CHEMBL5189788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182992 | — | IC50 | = | 14360.0 | nM | 4.84 |
| CHEMBL5202341 | — | IC50 | = | 16490.0 | nM | 4.78 |
| CHEMBL5191946 | — | IC50 | = | 20370.0 | nM | 4.69 |
| CHEMBL5200876 | — | IC50 | = | 22970.0 | nM | 4.64 |
| CHEMBL5199394 | — | IC50 | = | 28780.0 | nM | 4.54 |
| CHEMBL5180206 | — | IC50 | = | 35460.0 | nM | 4.45 |
| CHEMBL202701 | — | IC50 | = | 40320.0 | nM | 4.39 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 48450.0 | nM | 4.32 |
| CHEMBL5177844 | — | IC50 | = | 74990.0 | nM | 4.12 |
| CHEMBL5194479 | — | IC50 | = | 76700.0 | nM | 4.12 |
| CHEMBL5199999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5208972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5192649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5188191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5176164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5193777 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5199897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5172872 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5201769 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5203491 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5185075 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5181989 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5189788 | — | IC50 | > | 100000.0 | nM | - |