Assay Detail
Binding
CHEMBL5118486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to NME4 in human MCF7 cell lysate by pull down assay based LC-MS/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Subcellular | Lysate |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleoside diphosphate kinase, mitochondrial (CHEMBL4488) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.76 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204662 | — | — | 1 | 5.11 |
| CHEMBL5176252 | — | — | 1 | 4.84 |
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204662 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5176252 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1201346 | BALSALAZIDE | EC50 | = | 45800.0 | nM | 4.34 |