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Assay Detail

CHEMBL5118626

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Binding
Inhibition of glycoprotein in luciferase expressing pseudotyped Ebola virus infected in human Huh-7 cells assessed as inhibition of viral entry by measuring inhibition of virus-expressed reporter bioluminescence pretreated with cells for 30 mins followed by incubation with pseudotyped virus for 2 days by luciferase reporter assay
ChEMBL ↗
75
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ebolavirus
Cell Type Huh-7
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold.
Han S, Li H, Chen W, Yang L, Tong X, Zuo J, Hu Y.
Eur J Med Chem (2022) 240 : 114608 -114608
PubMed 35872393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 5.86 7.30
IC90 37 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5190865 — — 2 7.30
CHEMBL1655 TOREMIFENE 4.0 2 6.77
CHEMBL5199511 — — 2 6.64
CHEMBL5187086 — — 2 6.62
CHEMBL5170568 — — 2 6.51
CHEMBL5188576 — — 2 6.46
CHEMBL5186726 — — 2 6.28
CHEMBL5187448 — — 2 6.27
CHEMBL5180357 — — 2 6.23
CHEMBL5191132 — — 2 6.21
CHEMBL5179065 — — 2 6.19
CHEMBL5208276 — — 2 6.19
CHEMBL5170387 — — 2 6.16
CHEMBL5200629 — — 2 6.10
CHEMBL5204139 — — 2 6.00
CHEMBL5203285 — — 2 5.97
CHEMBL5191853 — — 2 5.96
CHEMBL5169592 — — 2 5.92
CHEMBL5184143 — — 2 5.91
CHEMBL5183238 — — 2 5.89
CHEMBL5181556 — — 2 5.83
CHEMBL5185910 — — 2 5.81
CHEMBL5188478 — — 2 5.77
CHEMBL5190801 — — 2 5.71
CHEMBL5185249 — — 2 5.69
CHEMBL5175268 — — 2 5.57
CHEMBL5207559 — — 2 5.52
CHEMBL5208339 — — 2 5.49
CHEMBL5201380 — — 2 5.38
CHEMBL5198065 — — 2 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5190865 — IC50 = 50.0 nM 7.30
CHEMBL1655 TOREMIFENE IC50 = 170.0 nM 6.77
CHEMBL5199511 — IC50 = 230.0 nM 6.64
CHEMBL5187086 — IC50 = 240.0 nM 6.62
CHEMBL5170568 — IC50 = 310.0 nM 6.51
CHEMBL5188576 — IC50 = 350.0 nM 6.46
CHEMBL5186726 — IC50 = 530.0 nM 6.28
CHEMBL5187448 — IC50 = 540.0 nM 6.27
CHEMBL5180357 — IC50 = 590.0 nM 6.23
CHEMBL5191132 — IC50 = 620.0 nM 6.21
CHEMBL5208276 — IC50 = 650.0 nM 6.19
CHEMBL5179065 — IC50 = 650.0 nM 6.19
CHEMBL5170387 — IC50 = 690.0 nM 6.16
CHEMBL5200629 — IC50 = 790.0 nM 6.10
CHEMBL5204139 — IC50 = 1000.0 nM 6.00
CHEMBL5203285 — IC50 = 1080.0 nM 5.97
CHEMBL5191853 — IC50 = 1110.0 nM 5.96
CHEMBL5169592 — IC50 = 1200.0 nM 5.92
CHEMBL5184143 — IC50 = 1240.0 nM 5.91
CHEMBL5183238 — IC50 = 1300.0 nM 5.89
CHEMBL5181556 — IC50 = 1480.0 nM 5.83
CHEMBL5185910 — IC50 = 1550.0 nM 5.81
CHEMBL5188478 — IC50 = 1710.0 nM 5.77
CHEMBL5190801 — IC50 = 1930.0 nM 5.71
CHEMBL5185249 — IC50 = 2060.0 nM 5.69
CHEMBL5175268 — IC50 = 2680.0 nM 5.57
CHEMBL5207559 — IC50 = 3010.0 nM 5.52
CHEMBL5208339 — IC50 = 3220.0 nM 5.49
CHEMBL5201380 — IC50 = 4200.0 nM 5.38
CHEMBL5198065 — IC50 = 4590.0 nM 5.34
CHEMBL5186194 — IC50 = 5930.0 nM 5.23
CHEMBL5189136 — IC50 = 6000.0 nM 5.22
CHEMBL5187042 — IC50 = 6470.0 nM 5.19
CHEMBL5184744 — IC50 = 6890.0 nM 5.16
CHEMBL114 SAQUINAVIR IC50 = 10500.0 nM 4.98
CHEMBL5172729 — IC50 = 13600.0 nM 4.87
CHEMBL5177164 — IC50 = 23130.0 nM 4.64
CHEMBL5186726 — IC90 = 1380.0 nM -
CHEMBL5199511 — IC90 = 720.0 nM -
CHEMBL5180357 — IC90 = 1460.0 nM -
CHEMBL5177164 — IC90 > 80000.0 nM -
CHEMBL5187448 — IC90 = 910.0 nM -
CHEMBL5191853 — IC90 = 1240.0 nM -
CHEMBL5169592 — IC90 = 1270.0 nM -
CHEMBL5184143 — IC90 = 3220.0 nM -
CHEMBL5189136 — IC90 = 18360.0 nM -
CHEMBL5184744 — IC90 = 21750.0 nM -
CHEMBL5172729 — IC90 = 43790.0 nM -
CHEMBL5189552 — IC50 > 80000.0 nM -
CHEMBL5204139 — IC90 = 2760.0 nM -