Assay Detail
Binding
CHEMBL5118630
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Inhibition of glycoprotein in luciferase expressing pseudotyped VSV infected in human Huh-7 cells assessed as inhibition of viral entry by measuring inhibition of virus-expressed reporter bioluminescence pretreated with cells for 30 mins followed by incubation with pseudotyped virus for 2 days by luciferase reporter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Vesicular stomatitis virus |
| Cell Type | Huh-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190865 | — | — | 1 | 5.52 |
| CHEMBL5200629 | — | — | 1 | 4.85 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 4.75 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190865 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5200629 | — | IC50 | = | 14090.0 | nM | 4.85 |
| CHEMBL1655 | TOREMIFENE | IC50 | = | 17790.0 | nM | 4.75 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 19340.0 | nM | 4.71 |